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LGS (N = 50)
|
Cryptogenic LGS (N = 28)
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Symptomatic LGS (N = 22)
|
p
|
|---|
|
Gender (male/female)
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38/12
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21/7
|
17/5
|
0.852
|
|
Age at conclusion of study (years)
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12.9 ± 6.5
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12.5 ± 6.1
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13.5 ± 7.1
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0.875
|
|
Age at evaluation (years)
|
9.3 ± 6.2
|
9.9 ± 5.6
|
8.4 ± 7.0
|
0.418
|
|
Age at seizure onset (months)
|
35.3 ± 29.6
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49.4 ± 29.5
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17.4 ± 18.1
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0.007*
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Seizure type
|
|
Tonic
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48 (96%)
|
26 (92.9%)
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22 (100.0%)
|
0.309
|
|
GTCS/secondary GTCS
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34 (68%)
|
18 (64.3%)
|
16 (72.7%)
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0.525
|
|
Complex/simple partial
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20 (40%)
|
11 (39.3%)
|
9 (40.9%)
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0.907
|
|
Atypical absence
|
20 (40%)
|
12 (42.9%)
|
8 (36.4%)
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0.642
|
|
Myoclonic
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16 (32%)
|
8 (28.6%)
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8 (36.4%)
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0.558
|
|
Spasms
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12 (24%)
|
1 (3.6%)
|
11 (50.0%)
|
0.001*
|
|
Drops
|
11 (22%)
|
5 (17.9%)
|
6 (27.3%)
|
0.650
|
|
Atonic
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8 (16%)
|
5 (17.9%)
|
3 (13.6%)
|
0.988
|
|
Status epilepticus
|
6 (12%)
|
3 (10.7%)
|
3 (13.6%)
|
1.000
|
|
EEG characteristics
|
|
Slow background activity
|
34 (68%)
|
18 (64.3%)
|
16 (72.7%)
|
0.525
|
|
Generalized polyspikes
|
49 (98%)
|
28 (100.0%)
|
21 (95.5%)
|
0.440
|
|
Diffuse SSW pattern
|
36 (72%)
|
22 (78.6%)
|
14 (63.6%)
|
0.243
|
|
Focal discharges
|
43 (86%)
|
24 (85.7%)
|
19 (86.4%)
|
1.000
|
|
Burst-suppression pattern
|
11 (22%)
|
6 (21.4%)
|
5 (22.7%)
|
1.000
|
|
Antiepileptic drugs
|
|
2
|
13 (26%)
|
10 (35.7%)
|
3 (13.6%)
|
0.768
|
|
≥ 3
|
37 (74%)
|
18 (64.3%)
|
19 (86.4%)
| |
|
Seizure free
|
14 (28%)
|
13 (46.4%)
|
1 (4.5%)
|
0.001*
|
- GTCS generalized tonic-clonic seizure, SSW slow spike-wave
- * p < 0.05 (two-sided) was statistically significant
